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lüll NF-kappaB signaling pathways regulated by CARMA family of scaffold proteins Blonska M; Lin XCell Res 2011[Jan]; 21 (1): 55-70The NF-kappaB family of transcription factors plays a crucial role in cell activation, survival and proliferation. Its aberrant activity results in cancer, immunodeficiency or autoimmune disorders. Over the past two decades, tremendous progress has been made in our understanding of the signals that regulate NF-kappaB activation, especially how scaffold proteins link different receptors to the NF-kappaB-activating complex, the IkappaB kinase complex. The growing number of these scaffolds underscores the complexity of the signaling networks in different cell types. In this review, we discuss the role of scaffold molecules in signaling cascades induced by stimulation of antigen receptors, G-protein-coupled receptors and C-type Lectin receptors, resulting in NF-kappaB activation. Especially, we focus on the family of Caspase recruitment domain (CARD)-containing proteins known as CARMA and their function in activation of NF-kappaB, as well as the link of these scaffolds to the development of various neoplastic diseases through regulation of NF-kappaB.|Adaptor Proteins, Signal Transducing/metabolism[MESH]|B-Cell CLL-Lymphoma 10 Protein[MESH]|CARD Signaling Adaptor Proteins/chemistry/*metabolism[MESH]|Caspases/metabolism[MESH]|Guanylate Cyclase/chemistry/*metabolism[MESH]|Humans[MESH]|Membrane Proteins/chemistry/*metabolism[MESH]|Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein[MESH]|NF-kappa B/*metabolism/physiology[MESH]|Neoplasm Proteins/metabolism[MESH]|Receptors, Antigen, T-Cell/metabolism[MESH]|Signal Transduction[MESH] |