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lüll TMEM16A protein: a new identity for Ca(2+)-dependent Cl(-) channels Ferrera L; Caputo A; Galietta LJPhysiology (Bethesda) 2010[Dec]; 25 (6): 357-63Ca(+)-dependent Cl(-) channels (CaCCs) play a variety of physiological roles in different organs and tissues, including transepithelial Cl(-) secretion, smooth muscle contraction, regulation of neuronal excitability, and transduction of sensory stimuli. The recent identification of TMEM16A protein as an important component of CaCCs should allow a better understanding of their physiological role, structure-function relationship, and regulatory mechanisms.|Animals[MESH]|Anoctamin-1[MESH]|Chloride Channels/chemistry/*metabolism[MESH]|Chlorides/*metabolism[MESH]|Epithelial Cells/metabolism[MESH]|Humans[MESH]|Kinetics[MESH]|Membrane Proteins/chemistry/*metabolism[MESH]|Myocytes, Smooth Muscle/metabolism[MESH]|Neoplasm Proteins/chemistry/*metabolism[MESH]|Neoplasms/metabolism[MESH]|Neurons/metabolism[MESH]|Protein Conformation[MESH]|Signal Transduction[MESH]|Structure-Activity Relationship[MESH] |