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Cell-specific aptamer-mediated targeted drug delivery Zhou J; Rossi JJOligonucleotides 2011[Feb]; 21 (1): 1-10Nucleic acid aptamers are in vitro-selected small, single-stranded DNA or RNA oligonucleotides that can specifically recognize their target on the basis of their unique 3-dimensional structures. Recent advances in the development of escort aptamers to deliver and enhance the efficacy of other therapeutic agents have drawn enthusiasm in exploiting cell-type-specific aptamers as drug delivery vehicles. This review mainly focuses on the recent developments of aptamer-mediated targeted delivery systems. We also place particular emphasis on aptamers evolved against cell membrane receptors and possibilities for translation to clinical applications.|Animals[MESH]|Aptamers, Nucleotide/administration & dosage/chemical synthesis/*therapeutic use[MESH]|Cell Line[MESH]|Drug Delivery Systems/*methods[MESH]|Humans[MESH]|Mice[MESH]|Neoplasms/drug therapy[MESH]|Organ Specificity[MESH]|SELEX Aptamer Technique[MESH]|Virus Diseases/drug therapy[MESH] |
