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Cell therapy for cardiovascular disease: a comparison of methods of delivery Dib N; Khawaja H; Varner S; McCarthy M; Campbell AJ Cardiovasc Transl Res 2011[Apr]; 4 (2): 177-81The field of myocardial regeneration utilizing novel cell-based therapies, gene transfer, and growth factors may prove to play an important role in the future management of ischemic heart disease and cardiomyopathy. Phases I and II clinical trials have been published for a variety of biologics utilizing four methods of delivery: systemic infusion, intracoronary infusion, transvenous coronary sinus, and intramyocardial. This review discusses the advantages and disadvantages of the delivery approaches above.|Cardiomyopathies/pathology/physiopathology/*surgery[MESH]|Humans[MESH]|Infusions, Intravenous[MESH]|Injections[MESH]|Myocardial Ischemia/pathology/physiopathology/*surgery[MESH]|Myocardium/*pathology[MESH]|Regeneration[MESH]|Regenerative Medicine/*methods[MESH]|Stem Cell Transplantation/adverse effects/*methods[MESH]|Treatment Outcome[MESH] |
