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Applications of patient-specific induced pluripotent stem cells; focused on disease modeling, drug screening and therapeutic potentials for liver disease Chun YS; Chaudhari P; Jang YYInt J Biol Sci 2010[Dec]; 6 (7): 796-805The recent advances in the induced pluripotent stem cell (iPSC) research have significantly changed our perspectives on regenerative medicine by providing researchers with a unique tool to derive disease-specific stem cells for study. In this review, we describe the human iPSC generation from developmentally diverse origins (i.e. endoderm-, mesoderm-, and ectoderm- tissue derived human iPSCs) and multistage hepatic differentiation protocols, and discuss both basic and clinical applications of these cells including disease modeling, drug toxicity screening/drug discovery, gene therapy and cell replacement therapy.|Cell- and Tissue-Based Therapy[MESH]|Drug Evaluation, Preclinical/methods[MESH]|Genetic Therapy[MESH]|Humans[MESH]|Induced Pluripotent Stem Cells/*cytology/metabolism[MESH]|Liver Diseases/drug therapy/metabolism/*pathology/therapy[MESH] |
