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IL-17 in protective immunity to intracellular pathogens Khader SA; Gopal RVirulence 2010[Sep]; 1 (5): 423-7The identification of a new T cell subset referred to as T helper 17 (Th17) cells and its role in protective immunity against extracellular bacterial infections is well established. In contrast, initial studies suggested that the IL-23-IL-17 pathway was not required for protection against intracellular pathogens such as mycobacterial infections. However, recent studies demonstrate that Th17-IL-23 pathway may play a crucial role in protective immunity against other intracellular pathogens by regulating the innate and adaptive immune responses. The current outlook on the role of IL-23-IL-17 pathway in protective immunity to intracellular pathogens is discussed here.|Animals[MESH]|Bacterial Infections/*immunology[MESH]|Chlamydia muridarum/immunology/pathogenicity[MESH]|Francisella tularensis/immunology/pathogenicity[MESH]|Humans[MESH]|Interleukin-17/*immunology[MESH]|Interleukin-23/immunology[MESH]|Models, Biological[MESH]|Mycobacterium bovis/immunology/pathogenicity[MESH]|Mycobacterium tuberculosis/immunology/pathogenicity[MESH]|Salmonella typhimurium/immunology/pathogenicity[MESH]|Th17 Cells/immunology[MESH] |
