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lüll T cell receptor signaling kinetics takes the stage Sykulev YSci Signal 2010[Dec]; 3 (153): pe50It has been long surmised that the strength of stimulation of the T cell receptor (TCR) determines the robustness of TCR-mediated signaling and the magnitude of a T cell response. However, it is becoming evident that the signal from the TCR develops over time to approach its steady-state, affinity-determined maximal extent and that variations in this time have a substantial effect on the responsiveness of T cells. Here, I discuss data that show that the kinetics of signal propagation in various segments of the TCR signaling network can influence the spatiotemporal regulation of the effector functions of T cells and the quality of the T cell response.|Cell Membrane/*metabolism[MESH]|Humans[MESH]|Immunity, Cellular/*immunology[MESH]|Kinetics[MESH]|Receptors, Antigen, T-Cell/*metabolism[MESH]|Signal Transduction/*immunology[MESH] |