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Non-canonical NF-kappaB signaling pathway Sun SCCell Res 2011[Jan]; 21 (1): 71-85The non-canonical NF-kappaB pathway is an important arm of NF-kappaB signaling that predominantly targets activation of the p52/RelB NF-kappaB complex. This pathway depends on the inducible processing of p100, a molecule functioning as both the precursor of p52 and a RelB-specific inhibitor. A central signaling component of the non-canonical pathway is NF-kappaB-inducing kinase (NIK), which integrates signals from a subset of TNF receptor family members and activates a downstream kinase, IkappaB kinase-alpha (IKKalpha), for triggering p100 phosphorylation and processing. A unique mechanism of NIK regulation is through its fate control: the basal level of NIK is kept low by a TRAF-cIAP destruction complex and signal-induced non-canonical NF-kappaB signaling involves NIK stabilization. Tight control of the fate of NIK is important, since deregulated NIK accumulation is associated with lymphoid malignancies.|Endonucleases[MESH]|Humans[MESH]|I-kappa B Kinase/metabolism[MESH]|NF-kappa B/*metabolism/physiology[MESH]|NF-kappaB-Inducing Kinase[MESH]|Nuclear Proteins/metabolism[MESH]|Protein Serine-Threonine Kinases/metabolism[MESH]|Signal Transduction[MESH] |
