Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
free
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
free free
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve Pubget Overpricing |
lüll NF-kappaB addiction and its role in cancer: one size does not fit all Chaturvedi MM; Sung B; Yadav VR; Kannappan R; Aggarwal BBOncogene 2011[Apr]; 30 (14): 1615-30Activation of nuclear factor (NF)-kappaB, one of the most investigated transcription factors, has been found to control multiple cellular processes in cancer including inflammation, transformation, proliferation, angiogenesis, invasion, metastasis, chemoresistance and radioresistance. NF-kappaB is constitutively active in most tumor cells, and its suppression inhibits the growth of tumor cells, leading to the concept of 'NF-kappaB addiction' in cancer cells. Why NF-kappaB is constitutively and persistently active in cancer cells is not fully understood, but multiple mechanisms have been delineated including agents that activate NF-kappaB (such as viruses, viral proteins, bacteria and cytokines), signaling intermediates (such as mutant receptors, overexpression of kinases, mutant oncoproteins, degradation of IkappaBalpha, histone deacetylase, overexpression of transglutaminase and iNOS) and cross talk between NF-kappaB and other transcription factors (such as STAT3, HIF-1alpha, AP1, SP, p53, PPARgamma, beta-catenin, AR, GR and ER). As NF-kappaB is 'pre-active' in cancer cells through unrelated mechanisms, classic inhibitors of NF-kappaB (for example, bortezomib) are unlikely to mediate their anticancer effects through suppression of NF-kappaB. This review discusses multiple mechanisms of NF-kappaB activation and their regulation by multitargeted agents in contrast to monotargeted agents, thus 'one size does not fit all' cancers.|Animals[MESH]|Carcinogens/metabolism[MESH]|Gene Expression Regulation, Neoplastic/genetics[MESH]|Humans[MESH]|I-kappa B Kinase/genetics/metabolism[MESH]|Mice[MESH]|Mutation[MESH]|NF-kappa B/*genetics/metabolism[MESH]|Neoplasms/*genetics/metabolism[MESH]|Signal Transduction/genetics[MESH]|Transcription Factors/genetics/metabolism[MESH] |