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lüll Self-antigen presentation by dendritic cells and lymphoid stroma and its implications for autoimmunity Lukacs-Kornek V; Turley SJCurr Opin Immunol 2011[Feb]; 23 (1): 138-45The induction and maintenance of T cell tolerance is essential to prevent autoimmunity. A combination of central and peripheral mechanisms acts to control autoreactive T cells. In secondary lymphoid organs, dendritic cells (DCs) presenting self-antigen were thought to play a major role in the induction of peripheral T cell tolerance. Multiple recent studies have demonstrated that DCs are not absolutely essential to induce and maintain tolerance. Furthermore, it has also been recently shown that non-hematopoietic stromal cells expressing peripheral tissue-restricted antigens can induce T cell tolerance, independently of DCs. Together these studies imply that peripheral tolerance is more complex than previously thought and a consequence of the tolerogenic functions of the hematopoietic and non-hematopoietic compartments within secondary lymphoid organs.|*Antigen Presentation[MESH]|*Autoimmunity[MESH]|Animals[MESH]|Dendritic Cells/*immunology[MESH]|Humans[MESH]|Lymphoid Tissue/*immunology[MESH]|Stromal Cells/*immunology[MESH] |