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lüll Peroxisome proliferator-activated receptor gamma and colorectal cancer Dai Y; Wang WHWorld J Gastrointest Oncol 2010[Mar]; 2 (3): 159-64Peroxisome proliferator-activated receptors (PPARs) are members of the nuclear hormone receptor superfamily and ligand-activated transcription factors. PPARgamma plays an important role in adipocyte differentiation, lipid storage and energy dissipation in adipose tissue, and is involved in the control of inflammatory reactions as well as in glucose metabolism through the improvement of insulin sensitivity. Growing evidence has demonstrated that activation of PPARgamma has an antineoplastic effect in tumors, including colorectal cancer. High expression of PPARgamma is detected in human colon cancer cell lines and adenocarcinoma. This review describes the molecular mechanisms by which PPARgamma regulates tumorigenesis in colorectal cancer, and examines current clinical trials evaluating PPARgamma agonists as therapeutic agents for colorectal cancer.ä |