Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
free
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
free free
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve Pubget Overpricing |
lüll Thyroid hormones and thyroid hormone receptors: effects of thyromimetics on reverse cholesterol transport Pedrelli M; Pramfalk C; Parini PWorld J Gastroenterol 2010[Dec]; 16 (47): 5958-64Reverse cholesterol transport (RCT) is a complex process which transfers cholesterol from peripheral cells to the liver for subsequent elimination from the body via feces. Thyroid hormones (THs) affect growth, development, and metabolism in almost all tissues. THs exert their actions by binding to thyroid hormone receptors (TRs). There are two major subtypes of TRs, TRalpha and TRbeta, and several isoforms (e.g. TRalpha1, TRalpha2, TRbeta1, and TRbeta2). Activation of TRalpha1 affects heart rate, whereas activation of TRbeta1 has positive effects on lipid and lipoprotein metabolism. Consequently, particular interest has been focused on the development of thyromimetic compounds targeting TRbeta1, not only because of their ability to lower plasma cholesterol but also due their ability to stimulate RCT, at least in pre-clinical models. In this review we focus on THs, TRs, and on the effects of TRbeta1-modulating thyromimetics on RCT in various animal models and in humans.|Animals[MESH]|Bile Acids and Salts/biosynthesis[MESH]|Biological Transport/*physiology[MESH]|Cholesterol/*metabolism[MESH]|Humans[MESH]|Protein Isoforms/metabolism[MESH]|Receptors, Thyroid Hormone/*metabolism[MESH]|Thyroid Hormones/chemistry/*metabolism[MESH] |