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Clinical significance of estrogen receptor phosphorylation Murphy LC; Seekallu SV; Watson PHEndocr Relat Cancer 2011[Feb]; 18 (1): R1-14Multiple sites of phosphorylation on human estrogen receptor alpha (ERalpha) have been identified by a variety of methodologies. Now with the emerging availability of phospho-site-specific antibodies to ERalpha, the relevance of phosphorylation of ERalpha in human breast cancer in vivo is being explored. Multiple phosphorylated sites in ERalpha can be detected in multiple breast tumor biopsy samples, providing evidence of their relevance to human breast cancer in vivo. Published data suggest that the detection in primary breast tumors of phosphorylation at some sites in ERalpha is associated with a better clinical outcome while phosphorylation at other sites is associated with a poorer clinical outcome most often in patients who have been treated with tamoxifen. This suggests the hypothesis that phospho-profiling of ERalpha in human breast tumors to establish an 'ERalpha phosphorylation code', may be a more accurate marker of prognosis and/or response to endocrine therapy in human breast cancer.|*Estrogens[MESH]|*Protein Processing, Post-Translational[MESH]|Antineoplastic Agents, Hormonal/pharmacology/therapeutic use[MESH]|Biopsy[MESH]|Breast Neoplasms/drug therapy/*metabolism[MESH]|Carcinoma/drug therapy/*metabolism[MESH]|Disease Progression[MESH]|Drug Resistance, Neoplasm[MESH]|Estrogen Receptor alpha/*metabolism/physiology[MESH]|Female[MESH]|Gene Expression Regulation, Neoplastic[MESH]|Humans[MESH]|Neoplasm Proteins/*metabolism/physiology[MESH]|Neoplasms, Hormone-Dependent/drug therapy/*metabolism[MESH]|Phosphorylation[MESH]|Proteasome Endopeptidase Complex/metabolism[MESH]|Protein Kinases/metabolism[MESH]|Selective Estrogen Receptor Modulators/pharmacology/therapeutic use[MESH]|Signal Transduction[MESH]|Structure-Activity Relationship[MESH]|Tamoxifen/pharmacology/therapeutic use[MESH]|Treatment Outcome[MESH] |
