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  • Becoming self-aware: the thymic education of regulatory T cells
  • Lio CW; Hsieh CS
  • Curr Opin Immunol 2011[Apr]; 23 (2): 213-9
  • The generation of Foxp3(+) regulatory T (Treg) cells in the thymus is essential for immune homeostasis. In the past several years, substantial progress has been made in understanding the mechanisms by which a minor portion of developing thymocytes are selected to become Treg cells. Although previously controversial, recent data support the importance of TCR specificity as a primary determinant for selecting self-reactive thymocytes to become Treg cells in a multi-step process involving cytokines, co-stimulatory molecules, and a variety of antigen-presenting cells. Importantly, the antigenic niche for Treg cell development appears to be typically quite small, implying the recognition of tissue-specific, rather than ubiquitous, self-antigens. Finally, it appears that an NF-kappaB transcription factor, c-Rel, may be the link between TCR recognition and the induction of Foxp3 expression, which is required for the function and stability of the natural Treg cell population.
  • |*Autoimmunity[MESH]
  • |Animals[MESH]
  • |Antigen-Presenting Cells/immunology[MESH]
  • |Cell Differentiation[MESH]
  • |Humans[MESH]
  • |Receptors, Antigen, T-Cell/immunology[MESH]
  • |T-Lymphocytes, Regulatory/cytology/*immunology[MESH]
  • |Thymus Gland/*immunology[MESH]

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    *<b>[ Becoming self-aware: the thymic education of regulatory T cells ]</b> Curr Opin Immunol 2011; 23(2) ; 213-9 Lio CW; Hsieh CS


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    Curr Opin Immunol

    213 2.23 2011