Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
free
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
free free
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve Pubget Overpricing |
lüll Polycystic kidney disease: pathogenesis and potential therapies Takiar V; Caplan MJBiochim Biophys Acta 2011[Oct]; 1812 (10): 1337-43Autosomal dominant polycystic kidney disease (ADPKD) is a prevalent, inherited condition for which there is currently no effective specific clinical therapy. The disease is characterized by the progressive development of fluid-filled cysts derived from renal tubular epithelial cells which gradually compress the parenchyma and compromise renal function. Current interests in the field focus on understanding and exploiting signaling mechanisms underlying disease pathogenesis as well as delineating the role of the primary cilium in cystogenesis. This review highlights the pathogenetic pathways underlying renal cyst formation as well as novel therapeutic targets for the treatment of PKD. This article is part of a Special Issue entitled: Polycystic Kidney Disease.|Animals[MESH]|Cilia/pathology/physiology[MESH]|Cyclic AMP/antagonists & inhibitors/physiology[MESH]|Cyst Fluid/metabolism[MESH]|Humans[MESH]|Polycystic Kidney, Autosomal Dominant/*drug therapy/*etiology/pathology/physiopathology[MESH]|Signal Transduction[MESH]|TRPP Cation Channels/genetics/physiology[MESH] |