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lüll Molecular pathogenesis of sporadic melanoma and melanoma-initiating cells Kong Y; Kumar SM; Xu XArch Pathol Lab Med 2010[Dec]; 134 (12): 1740-9Recent advances in molecular genetics and cancer stem cell biology have shed some light on the molecular basis of melanomagenesis. In this review, we will focus on major genetic alterations in the melanoma, particularly pathways involved in cell proliferation, apoptosis, and tumor suppression. The potential role of melanoma-initiating cells during melanomagenesis and progression will also be discussed. Understanding pathogenesis of melanoma may uncover new diagnostic clues and therapeutic targets for this increasingly prevalent disease.|*Gene Expression Regulation, Neoplastic[MESH]|Apoptosis/genetics[MESH]|Cell Proliferation[MESH]|Humans[MESH]|Melanocytes/*metabolism/pathology[MESH]|Melanoma/*genetics/metabolism/pathology/therapy[MESH]|Neoplastic Stem Cells/metabolism/pathology[MESH]|Prognosis[MESH]|Skin Neoplasms/*genetics/metabolism/pathology/therapy[MESH] |