Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
free
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
free free
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve Pubget Overpricing |
lüll Biomarkers in Barrett s esophagus and esophageal adenocarcinoma: predictors of progression and prognosis Ong CA; Lao-Sirieix P; Fitzgerald RCWorld J Gastroenterol 2010[Dec]; 16 (45): 5669-81Barrett's esophagus is a well-known premalignant lesion of the lower esophagus that is characterized by intestinal metaplasia of the squamous epithelium. It is clinically important due to the increased risk (0.5% per annum) of progression to esophageal adenocarcinoma (EA), which has a poor outcome unless diagnosed early. The current clinical management of Barrett's esophagus is hampered by the lack of accurate predictors of progression. In addition, when patients develop EA, the current staging modalities are limited in stratifying patients into different prognostic groups in order to guide the optimal therapy for an individual patient. Biomarkers have the potential to improve radically the clinical management of patients with Barrett's esophagus and EA but have not yet entered mainstream clinical practice. This is in contrast to other cancers like breast and prostate for which biomarkers are utilized routinely to inform clinical decisions. This review aims to highlight the most promising predictive and prognostic biomarkers in Barrett's esophagus and EA and to discuss what is required to move the field forward towards clinical application.|Adenocarcinoma/*diagnosis/genetics/pathology[MESH]|Barrett Esophagus/*diagnosis/genetics/pathology[MESH]|Biomarkers, Tumor/*analysis/genetics[MESH]|Cell Cycle Proteins/analysis[MESH]|Cell Proliferation[MESH]|Disease Progression[MESH]|Early Detection of Cancer[MESH]|Epigenesis, Genetic[MESH]|Esophageal Neoplasms/*diagnosis/genetics/pathology[MESH]|Genetic Markers[MESH]|Humans[MESH]|Loss of Heterozygosity[MESH]|Ploidies[MESH]|Predictive Value of Tests[MESH]|Prognosis[MESH] |