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lüll B7-h3 and its role in antitumor immunity Loos M; Hedderich DM; Friess H; Kleeff JClin Dev Immunol 2010[]; 2010 (ä): 683875B7-H3 is one of the most recently identified members of the B7/CD28 superfamily of costimulatory molecules serving as an accessory modulator of T-cell response. Recently, B7-H3 expression has been reported in several human cancers indicating an additional function of B7-H3 as a regulator of antitumor immunity. However, its precise physiologic role is still elusive, because both stimulatory and inhibitory capacities have been demonstrated. This paper summarizes the available data on B7-H3 in the regulation of T-cell response focusing on its potential role in antitumor immunity.|*Antigens, CD/immunology/therapeutic use[MESH]|*Biomarkers, Tumor/immunology/therapeutic use[MESH]|B7 Antigens[MESH]|Cytokines/biosynthesis/*immunology[MESH]|Female[MESH]|Humans[MESH]|Immunomodulation[MESH]|Lymphocyte Activation/*immunology[MESH]|Lymphocytes, Tumor-Infiltrating/immunology/metabolism[MESH]|Male[MESH]|Neoplasms/*immunology/physiopathology/therapy[MESH]|Receptors, Immunologic/*genetics/immunology/metabolism/therapeutic use[MESH]|Survival Analysis[MESH]|T-Lymphocytes/*immunology/metabolism[MESH] |