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Clinical practice of defibrillator implantation after myocardial infarction: impact of implant time: results from the PreSCD II registry Voller H; Kamke W; Klein HU; Block M; Reibis R; Treusch S; Contzen K; Wegscheider KEuropace 2011[Apr]; 13 (4): 499-508AIMS: Current guidelines recommend implantable cardioverter-defibrillator (ICD) therapy for primary prevention of sudden cardiac death in patients with the reduced left ventricular function (LVEF 40% of 1148 randomly selected patients from the cohort of 9616 patients with preserved LV function. After 36 months, only 142 patients (6.9%) had received an ICD; 82 (31.7%) of Group 1, 49 (7%) of Group 2, and 11 (1%) in Group 3. The ICD was implanted in 47% of all patients within 1 year after their index MI. Implantable cardioverter-defibrillator patients were predominantly characterized by low ejection fraction, but also by several other independent risk factors. Patients who received an ICD had an adjusted 44% lower mortality (hazard ratio 0.56, 95% confidence intervals 0.32-1.01; P = 0.053) than comparable patients without ICD therapy. All cause mortality of ICD recipients was significantly lower if the ICD was implanted later than 11 months after acute MI (P < 0.001). CONCLUSIONS: The PreSCD II registry demonstrated that the number of patients who develop a low LVEF (11 months) after MI.|*Defibrillators, Implantable[MESH]|*Practice Guidelines as Topic[MESH]|Aged[MESH]|Death, Sudden, Cardiac/*epidemiology/*prevention & control[MESH]|Female[MESH]|Germany[MESH]|Humans[MESH]|Male[MESH]|Middle Aged[MESH]|Myocardial Infarction/*therapy[MESH]|Proportional Hazards Models[MESH]|Registries[MESH]|Retrospective Studies[MESH]|Risk Factors[MESH]|Time Factors[MESH]|Treatment Outcome[MESH] |
