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Cell-penetrating peptide-functionalized quantum dots for intracellular delivery Liu BR; Huang YW; Chiang HJ; Lee HJJ Nanosci Nanotechnol 2010[Dec]; 10 (12): 7897-905Quantum dots (QDs) are luminescent semiconductor nanocrystals that are widely used as fluorescent probes in biomedical applications, including cellular imaging and tumor tracking. Cell-penetrating peptides (CPPs), also called protein transduction domains (PTDs), are short basic peptides that permeate cell membranes and are able to deliver a variety of macromolecule cargoes, such as DNAs, RNAs, proteins, and nanomaterials. Here we review strategies to couple QDs to CPPs, by either covalent linkages or noncovalent interactions, to provide a tool to study intracellular delivery. This facilitated transport of QDs by CPPs into cells is both simple and efficient. Accordingly, CPP-QD nanoparticles are likely to be of broad utility in biological research and advance the development of medical and pharmaceutical therapeutics.|*Quantum Dots[MESH]|Cell-Penetrating Peptides/*chemistry/*pharmacokinetics[MESH]|Drug Delivery Systems/*methods[MESH]|Nanocomposites/chemistry[MESH]|Pinocytosis[MESH]|Protein Transport[MESH] |
