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lüll Localization of dysfunction in major depressive disorder: prefrontal cortex and amygdala Murray EA; Wise SP; Drevets WCBiol Psychiatry 2011[Jun]; 69 (12): e43-54Despite considerable effort, the localization of dysfunction in major depressive disorder (MDD) remains poorly understood. We present a hypothesis about its localization that builds on recent findings from primate neuropsychology. The hypothesis has four key components: a deficit in the valuation of "self" underlies the core disorder in MDD; the medial frontal cortex represents "self"; interactions between the amygdala and cortical representations update their valuation; and inefficiency in using positive feedback by orbital prefrontal cortex contributes to MDD.|Amygdala/*physiopathology[MESH]|Animals[MESH]|Choice Behavior/physiology[MESH]|Depressive Disorder, Major/*physiopathology/psychology[MESH]|Ego[MESH]|Emotions/physiology[MESH]|Frontal Lobe/physiopathology[MESH]|Humans[MESH]|Prefrontal Cortex/*physiopathology[MESH]|Psychomotor Performance/physiology[MESH]|Reversal Learning/physiology[MESH]|Self Concept[MESH] |