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Ca(2)+ signaling in B cells Lyubchenko TScientificWorldJournal 2010[Nov]; 10 (ä): 2254-64An increase in intracellular Ca(2)+ concentration is one of the major initial steps in B-cell activation that occurs within minutes after antigen receptor (BCR) engagement. In recent years, significant advances have been made in characterizing molecular mechanisms of Ca(2)+ signaling in lymphocytes, although the majority of work was done on T cells. This mini-review discusses several underexplored areas of Ca(2)+ signaling in B cells: (1) Ca(2)+ signaling in immune synapse and multifaceted Ca(2)+ responses within a single cell, (2) source of Ca(2)+ involved in Ca(2)+-dependent protein phosphorylation events and the role of store-operated influx, (3) role of BCR coreceptors in Ca(2)+ signaling, and (4) Ca(2)+ signaling and maintenance of B-cell tolerance and clinical significance of Ca(2)+ signaling alterations.|*Calcium Signaling[MESH]|B-Lymphocytes/*metabolism[MESH]|Calcium/*metabolism[MESH]|Endoplasmic Reticulum/*metabolism[MESH]|Humans[MESH]|Models, Biological[MESH]|Phospholipase C gamma[MESH]|Phosphorylation[MESH]|Receptors, Antigen, B-Cell/metabolism[MESH]|Receptors, Complement 3d/metabolism[MESH] |
