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lüll LKB1 regulated pathways in lung cancer invasion and metastasis Marcus AI; Zhou WJ Thorac Oncol 2010[Dec]; 5 (12): 1883-6Metastasis is characterized by the ability of cancer cells to invade into adjacent tissue, intravasate into blood or lymphatic vessels, and extravasate into a distant tissue. Metastatic disease is primarily responsible for the low 5-year survival rate of non-small cell lung cancer (NSCLC), and therefore, an understanding of the molecular mechanisms that regulate NSCLC metastasis is clearly warranted. The serine/threonine kinase and tumor suppressor LKB1 is mutated in 30% of NSCLC tumors, and recent evidence points to a prominent role in NSCLC metastasis. This review summarizes LKB1-dependent invasion pathways where compromised LKB1 function could promote NSCLC metastasis.|AMP-Activated Protein Kinase Kinases[MESH]|AMP-Activated Protein Kinases/physiology[MESH]|Anoikis[MESH]|Carcinoma, Non-Small-Cell Lung/pathology[MESH]|Cell Adhesion[MESH]|Cell Polarity[MESH]|Humans[MESH]|Lung Neoplasms/*pathology[MESH]|Neoplasm Invasiveness[MESH]|Neoplasm Metastasis[MESH]|Protein Serine-Threonine Kinases/*physiology[MESH]|Signal Transduction/*physiology[MESH] |