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lüll The role of the transcription factor CREB in immune function Wen AY; Sakamoto KM; Miller LSJ Immunol 2010[Dec]; 185 (11): 6413-9CREB is a transcription factor that regulates diverse cellular responses, including proliferation, survival, and differentiation. CREB is induced by a variety of growth factors and inflammatory signals and subsequently mediates the transcription of genes containing a cAMP-responsive element. Several immune-related genes possess this cAMP-responsive element, including IL-2, IL-6, IL-10, and TNF-alpha. In addition, phosphorylated CREB has been proposed to directly inhibit NF-kappaB activation by blocking the binding of CREB binding protein to the NF-kappaB complex, thereby limiting proinflammatory responses. CREB also induces an antiapoptotic survival signal in monocytes and macrophages. In T and B cells, CREB activation promotes proliferation and survival and differentially regulates Th1, Th2, and Th17 responses. Finally, CREB activation is required for the generation and maintenance of regulatory T cells. This review summarizes current advances involving CREB in immune function--a role that is continually being defined.|Animals[MESH]|Cell Differentiation/immunology[MESH]|Cell Proliferation[MESH]|Cell Survival/immunology[MESH]|Cyclic AMP Response Element-Binding Protein/*physiology[MESH]|Humans[MESH]|Immunity, Cellular[MESH] |