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The IgH 3 regulatory region and its implication in lymphomagenesis Vincent-Fabert C; Fiancette R; Cogne M; Pinaud E; Denizot YEur J Immunol 2010[Dec]; 40 (12): 3306-11The 3' regulatory region (3'RR) located downstream of the IgH gene is the master element that controls class switch recombination and sustains high-level transcription at the plasma-cell stage. This latter role suggests that the 3'RR may be involved in oncogene deregulation during the frequent IgH translocation events associated with B-cell malignancies. A convincing demonstration of the essential contribution of 3'RR in lymphomagenesis has been provided by transgenic animal models. The mouse 3'RR shares a strong structural homology with the regulatory regions located downstream of each human Calpha gene. Mouse models exploring the role of the 3'RR in B-cell physiology and in malignancies should provide useful indications about the pathophysiology of human cell lymphocyte proliferation.|3' Untranslated Regions/*genetics/immunology[MESH]|Animals[MESH]|B-Lymphocytes/*immunology[MESH]|Cell Transformation, Neoplastic/genetics/immunology[MESH]|Disease Models, Animal[MESH]|Humans[MESH]|Immunoglobulin Heavy Chains/*genetics[MESH]|Lymphoma/*genetics/pathology[MESH]|Mice[MESH]|Mice, Transgenic[MESH]|Regulatory Sequences, Nucleic Acid/*genetics/immunology[MESH] |
