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Mouse models of inherited cancer syndromes Jahid S; Lipkin SHematol Oncol Clin North Am 2010[Dec]; 24 (6): 1205-28Animal models of cancer have been instrumental in understanding the progression and therapy of hereditary cancer syndromes. The ability to alter the genome of an individual mouse cell in both constitutive and inducible approaches has led to many novel insights into their human counterparts. In this review, knockout mouse models of inherited human cancer syndromes are presented and insights from the study of these models are highlighted.|*Disease Models, Animal[MESH]|Animals[MESH]|Genetic Predisposition to Disease/*genetics[MESH]|Humans[MESH]|Mice[MESH]|Mice, Knockout[MESH]|Mutation[MESH]|Neoplastic Syndromes, Hereditary/*genetics[MESH] |
