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Tuberous sclerosis complex renal disease Dixon BP; Hulbert JC; Bissler JJNephron Exp Nephrol 2011[]; 118 (1): e15-20Although not as common as other genetic renal diseases such as autosomal dominant polycystic kidney disease, patients with tuberous sclerosis complex frequently have significant renal involvement. Recent revelations in the cell biology of these renal disease manifestations as well as effective therapies for tuberous sclerosis complex-related renal issues have heralded hope of improved renal survival and improved quality of life for the TSC patient. This review specifically addresses some of the major renal manifestations of this disease.|Angiomyolipoma/etiology[MESH]|Humans[MESH]|Kidney Diseases, Cystic/etiology[MESH]|Kidney Neoplasms/etiology[MESH]|Mutation/genetics[MESH]|Nephrolithiasis/etiology[MESH]|Tuberous Sclerosis Complex 1 Protein[MESH]|Tuberous Sclerosis Complex 2 Protein[MESH]|Tuberous Sclerosis/*complications/genetics/*physiopathology[MESH]|Tumor Suppressor Proteins/genetics[MESH] |
