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lüll Selective estrogen receptor modulators as brain therapeutic agents Arevalo MA; Santos-Galindo M; Lagunas N; Azcoitia I; Garcia-Segura LMJ Mol Endocrinol 2011[Feb]; 46 (1): R1-9Selective estrogen receptor modulators (SERMs), used for the treatment of breast cancer, osteoporosis, and menopausal symptoms, affect the nervous system. Some SERMs trigger neuroprotective mechanisms and reduce neural damage in different experimental models of neural trauma, brain inflammation, neurodegenerative diseases, cognitive impairment, and affective disorders. New SERMs with specific actions on neurons and glial cells may represent promising therapeutic tools for the brain.|Animals[MESH]|Apoptosis/drug effects[MESH]|Brain Diseases/*drug therapy/metabolism[MESH]|Brain Injuries/drug therapy[MESH]|Brain/*drug effects/metabolism[MESH]|Encephalitis/drug therapy[MESH]|Humans[MESH]|Mood Disorders/drug therapy[MESH]|Neurodegenerative Diseases/drug therapy[MESH]|Neuroprotective Agents/pharmacology/*therapeutic use[MESH]|Oxidative Stress/drug effects[MESH]|Raloxifene Hydrochloride/therapeutic use[MESH]|Receptors, Estrogen/*metabolism[MESH]|Selective Estrogen Receptor Modulators/*therapeutic use[MESH]|Tamoxifen/therapeutic use[MESH] |