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lüll 14-3-3zeta as a prognostic marker and therapeutic target for cancer Neal CL; Yu DExpert Opin Ther Targets 2010[Dec]; 14 (12): 1343-54IMPORTANCE OF THE FIELD: The ubiquitously expressed 14-3-3zeta protein is involved in numerous important cellular pathways involved in cancer. Recent research suggests 14-3-3zeta may play a central role regulating multiple pathways responsible for cancer initiation and progression. This review will provide an overview of 14-3-3 proteins and address the role of 14-3-3zeta overexpression in cancer. AREAS COVERED IN THIS REVIEW: The review covers the basic role of 14-3-3 in regulation of multiple pathways with a focus on 14-3-3zeta as a clinically relevant biomarker for cancer recurrence. WHAT THE READER WILL GAIN: 14-3-3zeta overexpression has been found in multiple cancers; however, the clinical implications were unclear. Recently, 14-3-3zeta has been identified as a biomarker for poor prognosis and chemoresistance in multiple tumor types, indicating a potential clinical application for using 14-3-3zeta in selecting treatment options and predicting cancer patients' outcome. TAKE HOME MESSAGE: 14-3-3zeta is a potential prognostic marker of cancer recurrence and predictive marker for therapeutic resistance. The overexpression of 14-3-3zeta in multiple cancers suggests that it may be a common target to intervene tumor progression; therefore, more efforts are needed for the development of 14-3-3 inhibitors.|14-3-3 Proteins/*metabolism[MESH]|Animals[MESH]|Antineoplastic Agents/therapeutic use[MESH]|Biomarkers, Tumor[MESH]|Cell Line, Tumor[MESH]|Drug Resistance, Neoplasm[MESH]|Humans[MESH]|Molecular Targeted Therapy[MESH]|Neoplasm Recurrence, Local[MESH]|Neoplasms/*drug therapy/*metabolism[MESH]|Prognosis[MESH] |