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lüll Mechanisms of StpA-mediated RNA remodeling Doetsch M; Gstrein T; Schroeder R; Furtig BRNA Biol 2010[Nov]; 7 (6): 735-43In bacteria, transcription, translation and gene regulation are highly coupled processes. The achievement of a certain functional structure at a distinct temporal and spatial position is therefore essential for RNA molecules. Proteins that facilitate this proper folding of RNA molecules are called RNA chaperones. Here a prominent example from E. coli is reviewed: the nucleoid associated protein StpA. Based on its various RNA remodeling functions, we propose a mechanistic model that explains how StpA promotes RNA folding. Through transient interactions via the RNA backbone, thereby shielding repelling charges in RNA, it pre-positions the RNA molecules for the successful formation of transition states from encounter complexes.|DNA-Binding Proteins/*metabolism[MESH]|Escherichia coli Proteins/*metabolism[MESH]|Models, Biological[MESH]|Molecular Chaperones/chemistry/*metabolism[MESH]|RNA/*metabolism[MESH] |