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lüll The rate of decompensation and clinical progression of disease in people with cirrhosis: a cohort study Fleming KM; Aithal GP; Card TR; West JAliment Pharmacol Ther 2010[Dec]; 32 (11-12): 1343-50BACKGROUND: We lack population-based estimates of the rate of decompensation in people with compensated cirrhosis as well as estimates of the manner in which the disease progresses once identified. AIM: To determine the rate of decompensation and clinical progression of disease in patients with cirrhosis based upon clinical symptoms recorded electronically in general practice data. METHODS: Using Cox proportional hazards regression, we modelled the rate of decompensation for patients from the UK General Practice Research Database with a diagnosis of cirrhosis between 1987 and 2002. We determined the clinical progression in the first year following diagnosis and subsequently categorizing patients through time according to a simple clinical staging system agreed at the Baveno IV consensus conference. RESULTS: The rate of decompensation in patients with compensated cirrhosis was found to be 11% overall. The rate of decompensation was higher in the first year (at 31% compared with 7.3% afterwards) and in patients with an alcoholic aetiology. Patients with compensated cirrhosis had a 1-year probability of proceeding directly to death of 7% compared with 20% in patients with decompensated cirrhosis. CONCLUSIONS: Using data recorded in general practice records, it is possible to determine the rate of decompensation and the clinical progression of disease in people with cirrhosis.|*Disease Progression[MESH]|Adult[MESH]|Aged[MESH]|Cohort Studies[MESH]|Female[MESH]|General Practice[MESH]|Humans[MESH]|Liver Cirrhosis/*physiopathology[MESH]|Male[MESH]|Middle Aged[MESH]|Prognosis[MESH]|Regression Analysis[MESH]|Risk Factors[MESH]|Severity of Illness Index[MESH]|Survival Analysis[MESH]|Time Factors[MESH]|United Kingdom[MESH] |