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lüll Nociceptors: the sensors of the pain pathway Dubin AE; Patapoutian AJ Clin Invest 2010[Nov]; 120 (11): 3760-72Specialized peripheral sensory neurons known as nociceptors alert us to potentially damaging stimuli at the skin by detecting extremes in temperature and pressure and injury-related chemicals, and transducing these stimuli into long-ranging electrical signals that are relayed to higher brain centers. The activation of functionally distinct cutaneous nociceptor populations and the processing of information they convey provide a rich diversity of pain qualities. Current work in this field is providing researchers with a more thorough understanding of nociceptor cell biology at molecular and systems levels and insight that will allow the targeted design of novel pain therapeutics.|Animals[MESH]|Hot Temperature[MESH]|Humans[MESH]|Ion Channels/metabolism[MESH]|Mechanotransduction, Cellular/physiology[MESH]|Nervous System/anatomy & histology/metabolism[MESH]|Nociceptors/cytology/*physiology[MESH]|Pain Threshold/physiology[MESH]|Pain/drug therapy/*metabolism/*physiopathology[MESH]|Sensation/physiology[MESH]|Signal Transduction/*physiology[MESH]|Skin[MESH] |