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lüll Lipsosomal amphotericin B for treatment of cutaneous leishmaniasis Wortmann G; Zapor M; Ressner R; Fraser S; Hartzell J; Pierson J; Weintrob A; Magill AAm J Trop Med Hyg 2010[Nov]; 83 (5): 1028-33Treatment options for cutaneous leishmaniasis in the United States are problematic because the available products are either investigational, toxic, and/or of questionable effectiveness. A retrospective review of patients receiving liposomal amphotericin B through the Walter Reed Army Medical Center for the treatment of cutaneous leishmaniasis during 2007-2009 was conducted. Twenty patients who acquired disease in five countries and with five different strains of Leishmania were treated, of whom 19 received a full course of treatment. Sixteen (84%) of 19 experienced a cure with the initial treatment regimen. Three patients did not fully heal after an initial treatment course, but were cured with additional dosing. Acute infusion-related reactions occurred in 25% and mild renal toxicity occurred in 45% of patients. Although the optimum dosing regimen is undefined and the cost and toxicity may limit widespread use, liposomal amphotericin B is a viable treatment alternative for cutaneous leishmaniasis.|Adult[MESH]|Amphotericin B/administration & dosage/*therapeutic use[MESH]|Antiprotozoal Agents/administration & dosage/*therapeutic use[MESH]|Female[MESH]|Humans[MESH]|Leishmaniasis, Cutaneous/*drug therapy[MESH]|Liposomes[MESH]|Male[MESH]|Middle Aged[MESH]|Retrospective Studies[MESH]|Treatment Outcome[MESH]|Young Adult[MESH] |