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lüll Innate signaling networks in mucosal IgA class switching Chorny A; Puga I; Cerutti AAdv Immunol 2010[]; 107 (ä): 31-69The past 20 years have seen a growing interest over the control of adaptive immune responses by the innate immune system. In particular, considerable attention has been paid to the mechanisms by which antigen-primed dendritic cells orchestrate the differentiation of T cells. Additional studies have elucidated the pathways followed by T cells to initiate immunoglobulin responses in B cells. In this review, we discuss recent advances on the mechanisms by which intestinal bacteria, epithelial cells, dendritic cells, and macrophages cross talk with intestinal T cells and B cells to induce frontline immunoglobulin A class switching and production.|Animals[MESH]|Humans[MESH]|Immunity, Innate[MESH]|Immunity, Mucosal/genetics/*immunology[MESH]|Immunoglobulin A, Secretory/genetics/*immunology[MESH]|Immunoglobulin Class Switching/genetics/*immunology[MESH]|Intestinal Mucosa/*immunology[MESH]|Signal Transduction/genetics/*immunology[MESH] |