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lüll Oxygen administration in the care of neonates: a double-edged sword Dennery PAChin Med J (Engl) 2010[Oct]; 123 (20): 2938-42OBJECTIVE: To evaluate the use of oxygen in neonates in the past, present and future. DATA SOURCES: The data are mainly from Pubmed with relevant published articles from the 1940s to the present with some information gathered from web searches. STUDY SELECTION: Studies evaluating the use of oxygen in premature and term infants through history with original milestone articles included. RESULTS: There are still many unknowns about the proper use of oxygen in preterm and term infants but many studies suggest that both liberal use (resulting in a blood oxygen saturation of greater than 94%) as well as restrictive use (resulting in a blood oxygen saturation of less than 80% - 85%) are detrimental and have long term consequences on the infant. CONCLUSIONS: Definitive studies evaluating the appropriate concentration and duration of supplemental oxygen are ongoing and will help in the management of term and preterm infants requiring oxygen.|Animals[MESH]|Embryonic Development[MESH]|Humans[MESH]|Infant, Newborn[MESH]|Infant, Newborn, Diseases/*therapy[MESH]|Infant, Premature[MESH]|Oxygen/*therapeutic use/toxicity[MESH]|Practice Guidelines as Topic[MESH]|Retinopathy of Prematurity/therapy[MESH] |