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RhoA/Rho kinase: a novel therapeutic target in diabetic complications Zhou H; Li YJChin Med J (Engl) 2010[Sep]; 123 (17): 2461-6OBJECTIVE: To reveal the roles of Rho kinase (ROCK) in the mechanisms of complications in diabetes by reviewing the correlations between ROCK and related complications in diabetes. DATA SOURCES: The data used in the present article were mainly from PubMed with relevant English articles published from 1998 to 2010. The search terms were "ROCK" and "diabetes". STUDY SELECTION: Original articles including the roles of ROCK or its inhibitors in diabetic complications and review articles about the biological character of ROCK were selected. RESULTS: The activity and expression of ROCK were up-regulated in the models of type 1 or type 2 diabetes animals and the cultured cells with concentrations of high glucose, ROCK activation was associated with the development or progression of complications in diabetes. Inhibition of RhoA/ROCK pathway prevented or ameliorated the pathologic changes of diabetic complications, and ROCK has been regarded as a key target for treatment of these complications. CONCLUSION: RhoA/ROCK signaling plays important roles in the pathogenesis of long-term complications in diabetes and ROCK inhibitors are becoming a promising solution to treatments of complications in diabetes.|Animals[MESH]|Cardiomyopathies/etiology[MESH]|Diabetes Complications/*etiology/therapy[MESH]|Humans[MESH]|Sexual Dysfunction, Physiological/etiology[MESH]|Signal Transduction[MESH]|Urinary Bladder Diseases/etiology[MESH]|rho-Associated Kinases/antagonists & inhibitors/chemistry/*physiology[MESH]|rhoA GTP-Binding Protein/antagonists & inhibitors/chemistry/*physiology[MESH] |
