Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
free
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
free free
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve Pubget Overpricing |
lüll Interaction of nanoparticles and cell-penetrating peptides with skin for transdermal drug delivery Desai P; Patlolla RR; Singh MMol Membr Biol 2010[Oct]; 27 (7): 247-59Topical or transdermal drug delivery is challenging because the skin acts as a natural and protective barrier. Therefore, several methods have been examined to increase the permeation of therapeutic molecules into and through the skin. One approach is to use the nanoparticulate delivery system. Starting with liposomes and other vesicular systems, several other types of nanosized drug carriers have been developed such as solid lipid nanoparticles, nanostructured lipid carriers, polymer-based nanoparticles and magnetic nanoparticles for dermatological applications. This review article discusses how different particulate systems can interact and penetrate into the skin barrier. In this review, the effectiveness of nanoparticles, as well as possible mode of actions of nanoparticles, is presented. In addition to nanoparticles, cell-penetrating peptide (CPP)-mediated drug delivery into the skin and the possible mechanism of CPP-derived delivery into the skin is discussed. Lastly, the effectiveness and possible mechanism of CPP-modified nanocarriers into the skin are addressed.|*Skin/anatomy & histology/metabolism[MESH]|Administration, Cutaneous[MESH]|Animals[MESH]|Cell-Penetrating Peptides/*administration & dosage/chemistry[MESH]|Drug Carriers/chemistry[MESH]|Drug Delivery Systems/*methods[MESH]|Humans[MESH]|Lipids/chemistry[MESH]|Liposomes/*pharmacokinetics[MESH]|Nanoparticles/*administration & dosage/chemistry[MESH]|Pharmaceutical Preparations/administration & dosage/chemistry[MESH]|Rats[MESH] |