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lüll Hem-1: putting the "WAVE" into actin polymerization during an immune response Park H; Chan MM; Iritani BMFEBS Lett 2010[Dec]; 584 (24): 4923-32Most active processes by immune cells including adhesion, migration, and phagocytosis require the coordinated polymerization and depolymerization of filamentous actin (F-actin), which is an essential component of the actin cytoskeleton. This review focuses on a newly characterized hematopoietic cell-specific actin regulatory protein called hematopoietic protein-1 [Hem-1, also known as Nck-associated protein 1-like (Nckap1l or Nap1l)]. Hem-1 is a component of the "WAVE [WASP (Wiskott-Aldrich syndrome protein)-family verprolin homologous protein]" complex, which signals downstream of activated Rac to stimulate F-actin polymerization in response to immuno-receptor signaling. Genetic studies in cell lines and in mice suggest that Hem-1 regulates F-actin polymerization in hematopoietic cells, and may be essential for most active processes dependent on reorganization of the actin cytoskeleton in immune cells.|Actins/*metabolism[MESH]|Animals[MESH]|Biopolymers/*metabolism[MESH]|Cell Adhesion[MESH]|Cell Movement[MESH]|Cytoskeleton/metabolism[MESH]|Humans[MESH]|Macrophages/immunology[MESH]|Membrane Proteins/*physiology[MESH]|Mice[MESH]|Neutrophils/immunology[MESH]|Phagocytosis[MESH]|rho GTP-Binding Proteins/metabolism[MESH] |