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Expanding roles for ThPOK in thymic development Kappes DJImmunol Rev 2010[Nov]; 238 (1): 182-94The role of the zinc finger transcription factor ThPOK (T-helper-inducing POZ-Kruppel-like factor) in promoting commitment of alphabeta T cells to the CD4 lineage is now well established. New results indicate that ThPOK is also important for the development and/or acquisition of effector functions by other T cell subsets, including several not marked by CD4 expression, i.e. double-negative invariant natural killer T (iNKT) cells, gammadelta cells, and even memory CD8(+) T cells. There is compelling evidence that ThPOK expression in most or all of these cases is dependent on T-cell receptor signaling and that differences in relative TCR signal strength/length may induce different levels of ThPOK expression. The developmental consequences of ThPOK expression vary according to cell type, which may partly reflect differences in ThPOK levels and/or in transcriptional networks between cell types.|Animals[MESH]|CD4-Positive T-Lymphocytes/*immunology[MESH]|DNA-Binding Proteins/*immunology[MESH]|Gene Expression Regulation, Developmental/immunology[MESH]|Gene Regulatory Networks/immunology[MESH]|Humans[MESH]|Natural Killer T-Cells/immunology[MESH]|Receptors, Antigen, T-Cell, alpha-beta/*immunology[MESH]|Signal Transduction/immunology[MESH]|T-Lymphocyte Subsets/*immunology[MESH]|Thymus Gland/embryology/growth & development/*immunology[MESH]|Transcription Factors/*immunology[MESH] |
