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E proteins and the regulation of early lymphocyte development de Pooter RF; Kee BLImmunol Rev 2010[Nov]; 238 (1): 93-109Lymphopoiesis generates mature B, T, and NK lymphocytes from hematopoietic stem cells via a series of increasingly restricted developmental intermediates. The transcriptional networks that regulate these fate choices are composed of both common and lineage-specific components, which combine to create a cellular context that informs the developmental response to external signals. E proteins are an important factor during lymphopoiesis, and E2A in particular is required for normal T- and B-cell development. Although the other E proteins, HEB and E2-2, are expressed during lymphopoiesis and can compensate for some of E2A's activity, E2A proteins have non-redundant functions during early T-cell development and at multiple checkpoints throughout B lymphopoiesis. More recently, a role for E2A has been demonstrated in the generation of lymphoid-primed multipotent progenitors and shown to favor their specification toward lymphoid over myeloid lineages. This review summarizes both our current understanding of the wide-ranging functions of E proteins during the development of adaptive lymphocytes and the novel functions of E2A in orchestrating a lymphoid-biased cellular context in early multipotent progenitors.|*Gene Expression Regulation, Developmental/immunology[MESH]|Animals[MESH]|B-Lymphocytes/*immunology[MESH]|Basic Helix-Loop-Helix Transcription Factors/*immunology[MESH]|Cell Lineage[MESH]|GATA3 Transcription Factor/immunology[MESH]|Humans[MESH]|Lymphoid Progenitor Cells/immunology[MESH]|Lymphopoiesis/genetics/immunology[MESH]|Multipotent Stem Cells/*immunology[MESH]|Protein Binding[MESH]|T-Lymphocytes/*immunology[MESH] |
