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lüll Trials and tribulations in systemic lupus erythematosus Wofsky DBull NYU Hosp Jt Dis 2010[]; 68 (3): 175-8The pace of clinical trials activity in systemic lupus erythematosus (SLE) continues to accelerate. After decades of reliance on largely empiric approaches, a solid evidence-based foundation to guide our use of traditional agents, such as cyclophosphamide and azathioprine, is finally developing. In addition, we are learning how to integrate relatively new immunosuppressive agents, such as mycophenolate mofetil, into the treatment of SLE. These advances provide an important backdrop for recent trials designed to determine the potential value of several promising biologic therapies for SLE.|*Clinical Trials as Topic[MESH]|Evidence-Based Medicine[MESH]|Humans[MESH]|Immunosuppressive Agents/*therapeutic use[MESH]|Lupus Erythematosus, Systemic/*drug therapy[MESH]|Treatment Outcome[MESH] |