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Array-based technology and recommendations for utilization in medical genetics practice for detection of chromosomal abnormalities Manning M; Hudgins LGenet Med 2010[Nov]; 12 (11): 742-5Laboratory evaluation of patients with developmental delay/intellectual disability, congenital anomalies, and dysmorphic features has changed significantly in the last several years with the introduction of microarray technologies. Using these techniques, a patient's genome can be examined for gains or losses of genetic material too small to be detected by standard G-banded chromosome studies. This increased resolution of microarray technology over conventional cytogenetic analysis allows for identification of chromosomal imbalances with greater precision, accuracy, and technical sensitivity. A variety of array-based platforms are now available for use in clinical practice, and utilization strategies are evolving. Thus, a review of the utility and limitations of these techniques and recommendations regarding present and future application in the clinical setting are presented in this study.|*Chromosome Aberrations[MESH]|Chromosome Disorders/*diagnosis[MESH]|Genetics, Medical/*standards[MESH]|Humans[MESH]|Oligonucleotide Array Sequence Analysis/*standards[MESH] |
