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Cyclophilin A: promising new target in cardiovascular therapy Satoh K; Shimokawa H; Berk BCCirc J 2010[Nov]; 74 (11): 2249-56Cyclophilin A (CyPA) has been studied as a multifunctional protein that is upregulated in a variety of inflammatory conditions, such as rheumatoid arthritis, autoimmune disease, and cancer. CyPA has been classified as an immunophilin and has a variety of intracellular functions, including intracellular signaling, protein trafficking, and the regulation of other proteins activity. Besides its intracellular functions, CyPA is a secreted molecule that has a physiological and pathological role in cardiovascular diseases, making it a potential biomarker and mediator in cardiovascular diseases, such as vascular stenosis, atherosclerosis, and abdominal aortic aneurysms.|Animals[MESH]|Cardiovascular Diseases/metabolism/pathology/*therapy[MESH]|Cardiovascular System/*metabolism/pathology[MESH]|Cell Proliferation[MESH]|Cyclophilin A/*metabolism[MESH]|Enzyme Activation[MESH]|Humans[MESH]|Matrix Metalloproteinases/metabolism[MESH]|Molecular Chaperones/*metabolism[MESH]|Muscle, Smooth, Vascular/metabolism/pathology[MESH]|Oxidative Stress[MESH]|Reactive Oxygen Species/metabolism[MESH]|Signal Transduction[MESH] |
