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RNA processing and export Hocine S; Singer RH; Grunwald DCold Spring Harb Perspect Biol 2010[Dec]; 2 (12): a000752Messenger RNAs undergo 5' capping, splicing, 3'-end processing, and export before translation in the cytoplasm. It has become clear that these mRNA processing events are tightly coupled and have a profound effect on the fate of the resulting transcript. This processing is represented by modifications of the pre-mRNA and loading of various protein factors. The sum of protein factors that stay with the mRNA as a result of processing is modified over the life of the transcript, conferring significant regulation to its expression.|Active Transport, Cell Nucleus/physiology[MESH]|Cell Nucleus/*metabolism[MESH]|DNA-Binding Proteins/metabolism[MESH]|Gene Expression Regulation/*physiology[MESH]|RNA Processing, Post-Transcriptional/*physiology[MESH]|RNA, Messenger/*metabolism[MESH]|Transcription, Genetic/*physiology[MESH] |
