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lüll Estrogen signaling via estrogen receptor beta Zhao C; Dahlman-Wright K; Gustafsson JAJ Biol Chem 2010[Dec]; 285 (51): 39575-9Estrogens act by binding to and activating two estrogen receptors (ERs), ERalpha and ERbeta. Transcriptional regulation by ERs is controlled by a complex array of factors such as ER-ligand binding, the DNA sequence bound by ERs, ER-interacting cofactors, and chromatin context. This minireview will provide an overview of the most recent advances in the identification of ERbeta-regulated target gene networks and ERbeta DNA-binding sites. We also highlight the recent work establishing new roles of ERbeta signaling, including protective functions in the epithelial-mesenchymal transition and in atherosclerosis, as well as regulation of cell proliferation in the colon.|Animals[MESH]|Atherosclerosis/genetics/metabolism[MESH]|Cell Proliferation[MESH]|Colon/metabolism[MESH]|Epithelial-Mesenchymal Transition/physiology[MESH]|Estrogen Receptor alpha/genetics/metabolism[MESH]|Estrogen Receptor beta/genetics/*metabolism[MESH]|Humans[MESH]|Ligands[MESH]|Response Elements/physiology[MESH]|Signal Transduction/*physiology[MESH] |