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Endogenous ligands for nuclear receptors: digging deeper Schupp M; Lazar MAJ Biol Chem 2010[Dec]; 285 (52): 40409-15Nuclear receptors (NRs) are hormone-sensing transcription factors that translate dietary or endocrine signals into changes in gene expression. Therefore, the adoption of orphan NRs through the identification of their endogenous ligands is a key element for our understanding of their biology. In this minireview, we give an update on recent progress in regard to endogenous ligands for a cluster of NRs with high sequence homology, namely peroxisome proliferator-activated receptors alpha and gamma, Rev-erbalpha, and related receptors. This knowledge about the nature and physiology of these ligands may create new opportunities for therapeutic drug development.|Animals[MESH]|Gene Expression Regulation/*physiology[MESH]|Humans[MESH]|Ligands[MESH]|Receptors, Cytoplasmic and Nuclear/genetics/*metabolism[MESH]|Signal Transduction/*physiology[MESH]|Transcription, Genetic/*physiology[MESH] |
