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lüll Solid tumors associated with multiple endocrine neoplasias Almeida MQ; Stratakis CACancer Genet Cytogenet 2010[Nov]; 203 (1): 30-6We present an update on molecular and clinical genetics of solid tumors associated with the various multiple endocrine neoplasias (MEN) syndromes. MEN type 1 (MEN1) describes the association of pituitary, parathyroid, and pancreatic islet cell tumors with a variety of many other lesions. MEN type 2 (MEN2) conditions represent at least four different syndromes that associate pheochromocytoma with medullary thyroid carcinoma, hyperparathyroidism, and a number of other manifestations. Other pheochromocytoma-associated syndromes include von Hippel-Lindau disease; neurofibromatosis 1; the recently defined paraganglioma syndromes type 1, 3, and 4; Carney-Stratakis syndrome; and the Carney triad. Carney-Stratakis syndrome is characterized by the association of paragangliomas and familial gastrointestinal stromal tumors. In the Carney triad, patients can manifest gastrointestinal stromal tumors, lung chondroma, paraganglioma, adrenal adenoma and pheochromocytoma, esophageal leiomyoma, and other conditions. The Carney complex is yet another form of MEN that is characterized by skin tumors and pigmented lesions, myxomas, schwannomas, and various endocrine neoplasias.|Adrenal Gland Neoplasms/genetics[MESH]|Germ-Line Mutation[MESH]|Humans[MESH]|Multiple Endocrine Neoplasia Type 1/complications[MESH]|Multiple Endocrine Neoplasia Type 2a/complications[MESH]|Multiple Endocrine Neoplasia/*complications/genetics[MESH]|Neoplasms/*genetics[MESH]|Pheochromocytoma/genetics[MESH]|Thyroid Neoplasms/etiology[MESH] |