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lüll New one-pot methodologies for the modification or synthesis of alkaloid scaffolds Wahba AE; Hamann MTMar Drugs 2010[Aug]; 8 (8): 2395-416There are several avenues by which promising bioactive natural products can be produced in sufficient quantities to enable lead optimization and medicinal chemistry studies. The total synthesis of natural products is an important, but sometimes difficult, approach and requires the development of innovative synthetic methodologies to simplify the synthesis of complex molecules. Various classes of natural product alkaloids are both common and widely distributed in plants, bacteria, fungi, insects and marine organisms. This mini-review will discuss the scope, mechanistic insights and enantioselectivity aspects of selected examples of recently developed one-pot methods that have been published in 2009 for the synthesis of substituted piperidines, quinolizidines, pyrrolidines, hexahydropyrrolizines, octahydroindolizines and gamma-lactams. In addition, progress on the synthesis of beta-carboline (manzamine) alkaloids will also be discussed.|*Aquatic Organisms[MESH]|Alkaloids/*chemical synthesis/chemistry[MESH]|Animals[MESH]|Biological Products/*chemical synthesis/chemistry[MESH]|Lactams/chemical synthesis/chemistry[MESH]|Piperidines/chemical synthesis/chemistry[MESH]|Porifera[MESH]|Pyrrolidines/chemical synthesis/chemistry[MESH]|Stereoisomerism[MESH] |