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lüll Interleukin-26: an IL-10-related cytokine produced by Th17 cells Donnelly RP; Sheikh F; Dickensheets H; Savan R; Young HA; Walter MRCytokine Growth Factor Rev 2010[Oct]; 21 (5): 393-401IL-26 is classified as a member of the IL-10 cytokine family because it has limited sequence homology to IL-10 and the IL-10-related cytokines. The human IL-26 gene, IL26, is located on chromosome 12q15 between the genes for two other important class-2 cytokines, IFNG (IFN-gamma) and IL22 (IL-22). IL-26 is often co-expressed with IL-22 by activated T cells, especially Th17 cells. It signals through a heterodimeric receptor complex composed of the IL-20R1 and IL-10R2 chains. IL-26 receptors are primarily expressed on non-hematopoietic cell types, particularly epithelial cells. Signaling through IL-26 receptor complexes results in the activation of STAT1 and STAT3 with subsequent induction of IL-26-responsive genes. The biological functions of IL-26 have only begun to be defined.|Humans[MESH]|Interleukin-10/biosynthesis/genetics[MESH]|Interleukins/*biosynthesis/*genetics[MESH]|Th17 Cells/*immunology[MESH] |