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lüll Mutator phenotypes due to DNA replication infidelity Arana ME; Kunkel TASemin Cancer Biol 2010[Oct]; 20 (5): 304-11This article considers the fidelity of DNA replication performed by eukaryotic DNA polymerases involved in replicating the nuclear genome. DNA replication fidelity can vary widely depending on the DNA polymerase, the composition of the error, the flanking sequence, the presence of DNA damage and the ability to correct errors. As a consequence, defects in processes that determine DNA replication fidelity can confer strong mutator phenotypes whose specificity can help determine the molecular nature of the defect.|*DNA Damage[MESH]|*DNA Repair[MESH]|*Mutation[MESH]|Animals[MESH]|Biomarkers[MESH]|DNA Mismatch Repair[MESH]|DNA Replication[MESH]|DNA-Directed DNA Polymerase/*genetics/*metabolism[MESH]|Genes, Neoplasm[MESH]|Humans[MESH]|Microsatellite Instability[MESH]|Neoplasms/genetics[MESH]|Phenotype[MESH]|Somatic Hypermutation, Immunoglobulin[MESH] |